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In this study, we established a morphine-induced constipation mouse model, characterized by small intestinal dysfunction, including reductions in fecal output, fecal water content, the motility and the transit rate of small intestines

Unlike the other medications studied, tirzepatide targets both GLP-1 and another hormone with related effects called GIP

Similarly, in cancer treatment modalities, the HGF mimics may be administered together with analgesics and other suitable drugs

However, due to its invasiveness, it should be offered preferentially to patients with exhausted non-pharmacological and pharmacological treatment options

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